Objective: To evaluate the impact of Covid-19 (Pfizer-BioNTech BNT162b2) vaccination during the third trimester of pregnancy on maternal and neonatal outcomes. Design: A multicenter, retrospective computerized database. Population: Women who gave birth>24 weeks, in Isreal, between January-April 2021 with full records of Covid-19 disease and vaccination status. Methods: Women who received two doses of the vaccine were compared to unvaccinated women. Women who were recorded as having disease or a positive Covid-19 PCR swab during pregnancy or delivery were excluded from both study groups. Univariate analysis was followed by multivariate logistic regression. Main outcome measures: Composite adverse maternal outcomes. Secondary outcomes were vaccination rate and composite adverse neonatal outcomes. Results: Overall uptake of one or both vaccines were 40.2%, 712 women who received two doses of the Covid-19 vaccine were compared to 1,063 unvaccinated women. Maternal composite outcomes were comparable between the groups, however, women who received the vaccine had higher rates of elective CDs and lower rates of vacuum deliveries. An adjusted multivariable logistic regression analysis demonstrated that Covid-19 vaccination was not associated with maternal composite adverse outcome (aOR 0.8; 95% CI [0.61-1.03]); a significant reduction in the risk for neonatal composite adverse outcomes was observed (aOR 0.5; 95% CI [0.36-0.74]). Conclusion: In a motivated population covered by a National Health Insurance Plan, we found a 40.2% rate of vaccination for the Covid-19 vaccine during the third trimester of pregnancy which was not associated with adverse maternal outcomes and decreased the risk for neonatal adverse outcomes.
Fuente: An International Journal of Obstetrics ang Gynaecology
Published: 23 September 2021