Multisystem inflammatory syndrome in adults (MIS-A) is a hyperinflammatory illness related to SARSCoV-2 infection. The  characteristics of patients with this syndrome and the frequency with which it occurs among patients hospitalized after SARS-CoV-2 infection are unclear. Using the Centers for Disease Control and Prevention case definition for MIS-A, we created ICD-10-CM code and laboratory criteria to identify potential MIS-A patients in the Premier Healthcare Database Special COVID-19 Release, a database containing patient-level information on hospital discharges across the United States. Modified MIS-A criteria were applied to hospitalizations with discharge from March–December 2020. The proportion of hospitalizations meeting electronic health record criteria for MIS-A and descriptive statistics for patients in the potential MIS-A cohort were calculated. Of 34,515 SARS-CoV-2-related hospitalizations with complete clinical and laboratory data, 53 met modified criteria for MIS-A (0.15%). Median age was 62 years (IQR 52-74). Most patients met the severe cardiac illness criterion through either myocarditis (66.0%) or new-onset heart failure (35.9%). A total of 79.3% of patients required ICU admission, while 43.4% of patients in the cohort died. MIS-A appears to be a rare but severe outcome of SARS-CoV-2 infection. Additional studies are needed to investigate how this syndrome differs from severe COVID-19 in adults.

Fuente: Epidemiology & Infection