Two doses of the BNT162b2 mRNA vaccine is highly effective against SARS-CoV-2. Here we tested the antibody neutralization against Omicron SARS-CoV-2 after 2 and 3 doses of BNT162b2. Serum from vaccinated individuals was serially tested for their ability to neutralize wild-type SARS-CoV-2 (USA-WA1/2020) and an engineered USA-WA1/2020 bearing the Omicron spike glycoprotein. At 2 or 4 weeks post-dose-2, the neutralization geometric mean titers (GMTs) against the wild-type and Omicron-spike viruses were 511 and 20, respectively; at 1 month post-dose-3, the neutralization GMTs increased to 1342 and 336; and at 4 months post-dose-3, the neutralization GMTs decreased to 820 and 171. The data support a three-dose vaccine strategy and provide a glimpse into the durability of the neutralization response against Omicron.
Fuente: Cell Host & Microbe