In a recent study in Science, Bowen et al.1 report that mutations in Omicron sublineage’s spike protein enhance ACE2 binding, impair fusogenicity, and dampen the neutralizing activity of antibodies after vaccination or infection. The data describe how Omicron and especially the BA.5 variant evade neutralizing antibody responses and argue for using mRNA booster vaccination to increase immunity.

The SARS-CoV-2 Omicron variant (Pango lineage B.1.1.529) is genetically very different from the ancestral virus (Wuhan-Hu-1, Pango lineage B). It accounts for almost all infections during the first six months of 2022. Omicron comprises several sublineages and BA.5 now replaced the previously dominant sublineages BA.1, BA.2, and BA.2.12.1…

Fuente: Signal Transduction and Targeted Therapy

Published: 28 September 2022