COVID-19 vaccination of children is gaining global support (Committee on Infectious Diseases 2021) and data on immunogenicity and efficacy/effectiveness is increasing (Walter 2022; Frenck 2021; Han 2021). Chile has rapidly advanced in a national vaccination campaign for children: as of February 17 2022, 79% of children 3-17 years old had been fully vaccinated (Ministerio de Salud Chile 2022). Children 12-17 years old were vaccinated starting June 22nd 2021 with the mRNA Pfizer/BioNTech vaccine, followed weeks later by children 6-11 years old whom received the inactivated Sinovac vaccine. We previously reported a national COVID-19 IgG seropositivity study in adults vaccinated with either vaccines demonstrating the utility of large cross-sectional immunologic surveys using lateral flow tests (LFT) (Sauré 2022). We report here IgG seropositivity in vaccinated and non-vaccinated Chilean school-aged children, receiving the inactivated vaccine from Sinovac (CoronaVac) or the mRNA vaccine from Pfizer/BioNTech (BNT162b2) within one to twenty weeks before sample collection, or no vaccine. Data on IgG seropositivity among vaccinated children with inactivated as compared to mRNA vaccines is currently non-existent, and can provide important information for decision makers worldwide…

Fuente: International Journal of Infectious Diseases
Available online 25 April 2022